Strontium salt of cholic acid.



UNITED STATES PATENT OFFICE.

ROBERT WERN 01? LUD'WIGSHAFEN-0N-THE-RI-IINE, v GERMANY.

STBONTIUM SALT 0F CHOLIC ACID.

1 10 Drawing.

Specification of Letters Patent. Application filed Noveinber 29, 1912. Serial No. 734,200.

with. persons who suil'ered from gall-stone have shown that the strontium salt of the cholic acid which heretofore was unknown has a high anodyne power as against the pain from gall-stone, and that in this respect it is superior to the sodium sal acids which heretofore have proved appropriate particularly in the first stages of the disease. This power of the strontium salt of the cholic acid probably results from the fact, that the strontium salt of the cholic acid acts simultaneously in two directions.

- The cholic acid is the integrant part of the natural salts of the bile which prevent further secretionof cholesterin, while the strontium has the power to reduce intlammations.

The cholic acid-may be produced for example from an acid and a base, according to the well known methods of producing salts.

example: On the waterbath, l' dissolve on the one hand 4 kilograms of cholic acid in 420 liters of percentage ethyl alcohol, and on the other hand 1.3 kilograms of strontium hydroxid in liters of water. While the solution of the strontium hydroxid is still hot I filter the same while agitating into the ts of the bilious.

cholic acid which is likewise in The strontium hydroxid which at the beginninp might be precipitated is by itself dissolved again. the last third of the admixing process-the l solution ahot state.

times contains a little free cholic acid begins to be precipitated and it is preferably dis solved again by adding two liters of alcohol. The admixture of the solution of strontium hydroxid is interrupted, when a few drops of a solution of phenolphtalein show, that the neutralization is obtained. After regenerating the alcohol by distillation the product is allowed to -cool, whereby a crystal cake I of the strontium salt of the cholic acid is l obtained.

The strontium sal the composition i randst nd 5 t of the cholic acid has it crystallizes in the form 0f.eolorlcss very line hair bushes. loses its water when standing over sulfuric acid and isdecomposed by stronger acids into its components.

I claim:

cholic acid, which answers the formula 24 ::1J 5) z a z a crystallizes in the form of very fine colorless hair bushes, loses its water when standing over sulfuric acid, and is split into its components by stronger acids.

I In testimony whereof I hereunto aflix my signature in the presence of two witnesses.

DR. ROBERT WERNER.

/Vitnesses HERMAN): TAEGER,

Josnrn PEIFFER.

Afterwardwithhi I The herein described strontium salt of l Patented I)ec.9,1913.

strontium salt of the cholic acidwhich some- 

